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Course Catalog 2011-2012
BIO-2626 Metabolic Engineering, 4 cr |
Additional information
The course is suggested for 4-5 year Biotechnology or MSc Programme in Science and Bioengineering students.
Suitable for postgraduate studies
Person responsible
Matti Karp, Ville Santala, Suvi Santala
Lessons
| Study type | P1 | P2 | P3 | P4 | Summer | Implementations | Lecture times and places |
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Learning outcomes
After passing the course the student can link changes in the genotype level to changes in the phenotype level. The student will have an understanding of in silico metabolic models in metabolic engineering and their interplay with in vivo methods. The student will be able to apply metabolic engineering to different problems in modern industrial microbe strain improvement. The course will include a practical case example during which the student will carry out a short laboratory project exemplifying the power of metabolic engineering.
Content
| Content | Core content | Complementary knowledge | Specialist knowledge |
| 1. | Methods in metabolic engineering: in silico | ||
| 2. | Methods in metabolic engineering: in vivo | ||
| 3. | Microbial metabolism | Metabolic pathways | |
| 4. | Mutations affecting metabolism | Engineering gene expression | |
| 5. | Case example: in silico and in vivo laboratory |
Evaluation criteria for the course
The grade will be determined on the basis of an exam. To pass the course with a grade 1 the student will have to score at least 50 % of the maximum points in the exam. A good understanding the core content will suffice to a grade 3. In order to earn a grade 4 or 5 the student will have to have a good or excellent understanding of complementary knowledge.
Assessment scale:
Numerical evaluation scale (1-5) will be used on the course
Partial passing:
Study material
| Type | Name | Author | ISBN | URL | Edition, availability, ... | Examination material | Language |
| Lecture slides | Metabolic engineering | Suvi Santala | English | ||||
| Lecture slides | Metabolic engineering | Ville Santala | English |
Prerequisites
| Course | Mandatory/Advisable | Description |
| BIO-2602 Genetic Engineering and Molecular Biotechnology | Mandatory | 1 |
| BIO-2406 Microbial genetics | Mandatory |
1 . Or BIO-2601 Geeniteknologian menetelmät or book exam from Glick and Pasternak: Molecular biotechnology, 4th edition
Prerequisite relations (Requires logging in to POP)
Correspondence of content
There is no equivalence with any other courses
More precise information per implementation
| Implementation | Description | Methods of instruction | Implementation |
| Lectures Laboratory assignments |
Contact teaching: 44 % Distance learning: 0 % Self-directed learning: 56 % |