Course Catalog 2012-2013
Basic

Basic Pori International Postgraduate Open University

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Course Catalog 2012-2013

BIO-2626 Metabolic Engineering, 4 cr

Additional information

The course is suggested for 4-5 year Biotechnology or MSc Programme in Science and Bioengineering students.
Suitable for postgraduate studies

Person responsible

Matti Karp, Suvi Santala, Ville Santala

Lessons

Study type P1 P2 P3 P4 Summer Implementations Lecture times and places
Lectures

 

 

 
 4 h/week

 
BIO-2626 2012-01 Wednesday 12 - 14, FC117
Thursday 8 - 10, FC117

Learning outcomes

After passing the course the student can link changes in the genotype level to changes in the phenotype level. The student will have an understanding of in silico metabolic models in metabolic engineering and their interplay with in vivo methods. The student will be able to apply metabolic engineering to different problems in modern industrial microbe strain improvement. The course will include a practical case example during which the student will carry out a short laboratory project exemplifying the power of metabolic engineering.

Content

Content Core content Complementary knowledge Specialist knowledge
1. Methods in metabolic engineering: in silico     
2. Methods in metabolic engineering: in vivo     
3. Microbial metabolism   Metabolic pathways   
4. Mutations affecting metabolism   Engineering gene expression   
5. Case example: in silico and in vivo laboratory     

Evaluation criteria for the course

The grade will be determined on the basis of an exam. To pass the course with a grade 1 the student will have to score at least 50 % of the maximum points in the exam. A good understanding the core content will suffice to a grade 3. In order to earn a grade 4 or 5 the student will have to have a good or excellent understanding of complementary knowledge.

Assessment scale:

Numerical evaluation scale (1-5) will be used on the course

Partial passing:

Completion parts must belong to the same implementation

Study material

Type Name Author ISBN URL Edition, availability, ... Examination material Language
Lecture slides   Metabolic engineering   Suvi Santala            English  
Lecture slides   Metabolic engineering   Ville Santala            English  

Prerequisites

Course Mandatory/Advisable Description
BIO-2602 Geeniteknologian menetelmät ja molekulaarinen bioteknologia Mandatory   1
BIO-2406 Microbial genetics Mandatory    

1 . Or BIO-2601 Geeniteknologian menetelmät or book exam from Glick and Pasternak: Molecular biotechnology, 4th edition

Prerequisite relations (Requires logging in to POP)



Correspondence of content

Course Corresponds course  Description 
BIO-2626 Metabolic Engineering, 4 cr KEB-23406 Metabolic Engineering, 4 cr  

More precise information per implementation

Implementation Description Methods of instruction Implementation
BIO-2626 2012-01   Lectures
Laboratory assignments
   
Contact teaching: 44 %
Distance learning: 0 %
Self-directed learning: 56 %  

Last modified07.03.2012