Avainsanat

Yleiskuvaus

General objective is to gain knowledge at a molecular level from the genes to the active proteins or RNA molecules, in other words from genetic information to biological functions in prokaryotic cells and in some viruses with special emphasis in eukaryotic cells and species.

Osaamistavoitteet

During the course the student will learn to gain advanced knowledge and understanding of the mechanisms and machinery of expression of eukaryotic genes, emphasizing mammals, but also introducing material, where relevant, from studies of plant, fungal and invertebrate genes as well as of bacterial and viral genes.

Sisältö

Topics to be covered include the basal transcription machinery, transcriptional regulation, chromatin and epigenetics, polyadenylation, RNA splicing, nucleocytoplasmic transport, translational regulation, RNA interference and RNA turnover, -omics and organellar gene expression. The course will be concept-based rather than methods-based, and it will link mechanistic knowledge to concepts from development, physiology and evolution.

Toteutustavat

Arviointi

Kirjallisuus/Oppimateriaali

Textbook material: Jocelyn E. Krebs, Elliott S. Goldstein and Stephen T. Kilpatrick, Lewin's GENES X (2011). The examinable textbook material is from Lewin's GENES X as summarized below. Although it is mostly about eukaryotic gene expression, many of its aspects can only be properly understood by reference to the relevant processes in bacteria or viruses. Examinable material: Lewin's GENES X chapters 19-30.

Kokonaisuudet johon opintojakso kuuluu

2013–2014

Opintojakso opetusohjelmassa

Opetusohjelma ei ole enää voimassa. Tarkista tiedot voimassa olevasta opetusohjelmasta.

-