Tampere Imaging Facility - valomikroskopiakeskus

2024

Komulainen T, Daymond P, Hietanen KE, Kaartinen IS, Järvinen TAH.
Myofibroblasts reside in the middle dermis of the keloids but do not predict the response to injection therapies: a double-blinded, randomized, controlled trial.
Front Med (Lausanne). 2024 Mar 1;11:1293028. doi: 10.3389/fmed.2024.1293028.
PMID: 38495113 

Abraham BG, Haikarainen T, Vuorio J, Girych M, Virtanen AT, Kurttila A, Karathanasis C, Heilemann M, Sharma V, Vattulainen I, Silvennoinen O.
Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.
Sci Adv. 2024 Mar 8;10(10):eadl2097. doi: 10.1126/sciadv.adl2097.
PMID: 38457493 

Grönroos P, Mörö A, Puistola P, Hopia K, Huuskonen M, Viheriälä T, Ilmarinen T, Skottman H.
Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink.
Stem Cell Res Ther. 2024 Mar 14;15(1):81. doi: 10.1186/s13287-024-03672-w.
PMID: 38486306 

Szczodra A, Houaoui A, Salminen T, Hannula M, Gobbo VA, Ghanavati S, Miettinen S, Massera J.
Pore graded borosilicate bioactive glass scaffolds: in vitro dissolution and cytocompatibility.
J Mater Sci Mater Med. 2024 Mar 20;35(1):17. doi: 10.1007/s10856-024-06791-1.
PMID: 38507150 

Kärki T, Koskimäki S, Guenther C, Pirhonen J, Rajakylä K, Tojkander S.
Mechanosensitive TRPV4 channel guides maturation and organization of the bilayered mammary epithelium.
Sci Rep. 2024 Mar 21;14(1):6774. doi: 10.1038/s41598-024-57346-x.
PMID: 38514727 

Puistola P, Kethiri A, Nurminen A, Turkki J, Hopia K, Miettinen S, Mörö A, Skottman H.
Cornea-Specific Human Adipose Stem Cell-Derived Extracellular Matrix for Corneal Stroma Tissue Engineering.
ACS Appl Mater Interfaces. 2024 Apr 3;16(13):15761-15772. doi: 10.1021/acsami.3c17803.
PMID: 38513048

Kurki A, Paakinaho K, Hannula M, Karjalainen S, Kuismanen K, Hyttinen J, Miettinen S, Sartoneva R. 
Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse. 
Regen Biomater. 2024 May 24;11:rbae060. doi: 10.1093/rb/rbae060.
PMID: 38903561 

Kauppila M, Vattulainen M, Ihalainen TO, Mörö A, Ilmarinen T, Skottman H. 
Whole mount immunofluorescence analysis of fresh and stored human donor corneas highlights changes in limbal characteristics during storage. 
Ocul Surf. 2024 Jun 28;34:50-59. doi: 10.1016/j.jtos.2024.06.004. 
PMID: 38945477 

Vattulainen M, Smits JGA, Arts JA, Lima Cunha D, Ilmarinen T, Skottman H, Zhou H. 
Deciphering the heterogeneity of differentiating hPSC-derived corneal limbal stem cells through single-cell RNA sequencing. 
Stem Cell Reports. 2024 Jul 9;19(7):1010-1023. doi: 10.1016/j.stemcr.2024.06.001. 
PMID: 38942029 

Vuorenpää H, Valtonen J, Penttinen K, Koskimäki S, Hovinen E, Ahola A, Gering C, Parraga J, Kelloniemi M, Hyttinen J, Kellomäki M, Aalto-Setälä K, Miettinen S, Pekkanen-Mattila M. 
Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes. 
Cytotechnology. 2024 Aug;76(4):483-502. doi: 10.1007/s10616-024-00630-5. 
PMID: 38933872

 

2023

Hyväri L, Vanhatupa S, Ojansivu M, Kelloniemi M, Pakarinen TK, Hupa L, Miettinen S.
Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells.
Cells. 2023 Jan 5;12(2):224. doi: 10.3390/cells12020224.
PMID: 36672159

Alexanova A, Raitoharju E, Valtonen J, Aalto-Setälä K, Viiri LE.
Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism.
Sci Rep. 2023 Jan 30;13(1):1706. doi: 10.1038/s41598-023-28981-7.
PMID: 36717592

Hellinen L, Hongisto H, Ramsay E, Kaarniranta K, Vellonen KS, Skottman H, Ruponen M.
Comparison of barrier properties of outer blood-retinal barrier models - Human stem cell-based models as a novel tool for ocular drug discovery.
Eur J Pharm Biopharm. 2023 Mar;184:181-188. doi: 10.1016/j.ejpb.2023.01.026.
PMID: 36740104

Karema-Jokinen V, Koskela A, Hytti M, Hongisto H, Viheriälä T, Liukkonen M, Torsti T, Skottman H, Kauppinen A, Nymark S, Kaarniranta K.
Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients.
J Biol Chem. 2023 May 1:104770. doi: 10.1016/j.jbc.2023.104770.
PMID: 37137441

Mahmoud M, Juntunen M, Adnan A, Kummola L, Junttila IS, Kelloniemi M, Tyrväinen T, Huhtala H, Abd El Fattah AI, Amr K, El Erian AM, Patrikoski M, Miettinen S.
Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells.
Stem Cells. 2023 May 15;41(5):505-519. doi: 10.1093/stmcls/sxad021.
PMID: 36945068

Hammarén MM, Luukinen H, Sillanpää A, Remans K, Lapouge K, Custódio T, Löw C, Myllymäki H, Montonen T, Seeger M, Robertson J, Nyman TA, Savijoki K, Parikka M.
In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies.
mSystems. 2023 May 15:e0107322. doi: 10.1128/msystems.01073-22.
PMID: 37184670

Sartoneva R, Lyyra I, Juusela M, Sharma V, Huhtala H, Massera J, Kellomäki M, Miettinen S.
In vitro biocompatibility of polylactide and polybutylene succinate blends for urethral tissue engineering.
J Biomed Mater Res B Appl Biomater. 2023 May 18. doi: 10.1002/jbm.b.35268.
PMID: 37199480

Valtonen J, Prajapati C, Cherian RM, Vanninen S, Ojala M, Leivo K, Heliö T, Koskenvuo J, Aalto-Setälä K.
The Junctophilin-2 Mutation p.(Thr161Lys) Is Associated with Hypertrophic Cardiomyopathy Using Patient-Specific iPS Cardiomyocytes and Demonstrates Prolonged Action Potential and Increased Arrhythmogenicity.
Biomedicines. 2023 May 27;11(6):1558. doi: 10.3390/biomedicines11061558.
PMID: 37371654

Isosaari L, Vuorenpää H, Yrjänäinen A, Kapucu FE, Kelloniemi M, Pakarinen TK, Miettinen S, Narkilahti S.
Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types.
Cell Commun Signal. 2023 Jun 14;21(1):132. doi: 10.1186/s12964-023-01159-4.
PMID: 37316873

Mäntylä E, Montonen T, Azzari L, Mattola S, Hannula M, Vihinen-Ranta M, Hyttinen J, Vippola M, Foi A, Nymark S, Ihalainen TO.
Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina.
Mol Biol Cell. 2023 Jun 21:mbcE22090448. doi: 10.1091/mbc.E22-09-0448.
PMID: 37342871

Kerslake R, Belay B, Panfilov S, Hall M, Kyrou I, Randeva HS, Hyttinen J, Karteris E, Sisu C.
Transcriptional Landscape of 3D vs. 2D Ovarian Cancer Cell Models.
Cancers (Basel). 2023 Jun 26;15(13):3350. doi: 10.3390/cancers15133350.
PMID: 37444459

Isola J, Mäki M, Hils M, Pasternack R, Viiri K, Dotsenko V, Montonen T, Zimmermann T, Mohrbacher R, Greinwald R, Schuppan D. 
The Oral Transglutaminase 2 Inhibitor ZED1227 Accumulates in the Villous Enterocytes in Celiac Disease Patients during Gluten Challenge and Drug Treatment.
Int J Mol Sci. 2023 Jun 28;24(13):10815. doi: 10.3390/ijms241310815.
PMID: 37445994

Danielsson BE, George Abraham B, Mäntylä E, Cabe JI, Mayer CR, Rekonen A, Ek F, Conway DE, Ihalainen TO.
Nuclear lamina strain states revealed by intermolecular force biosensor.
Nat Commun. 2023 Jun 30;14(1):3867. doi: 10.1038/s41467-023-39563-6.
PMID: 37391402

Tervonen A, Korpela S, Nymark S, Hyttinen J, Ihalainen TO.
The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales.
Cell Mol Bioeng. 2023 Jul 13;16(5-6):475-495. doi: 10.1007/s12195-023-00772-0.
PMID: 38099211

Ilmarinen T, Vattulainen M, Kandhavelu J, Bremond-Gignac D, Aberdam D, Skottman H.
Production and limbal lineage commitment of aniridia patient-derived induced pluripotent stem cells.
Stem Cells. 2023 Aug 26:sxad067. doi: 10.1093/stmcls/sxad067.
PMID: 37632794

Suominen S, Hyypijev T, Venäläinen M, Yrjänäinen A, Vuorenpää H, Lehti-Polojärvi M, Räsänen M, Seppänen A, Hyttinen J, Miettinen S, Aalto-Setälä K, Viiri LE.
Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures.
Cells. 2023 Sep 27;12(19):2368. doi: 10.3390/cells12192368. 
PMID: 37830581

Belay B, Mäntylä E, Maibohm C, Silvestre OF, Hyttinen J, Nieder JB, Ihalainen TO. 
Substrate microtopographies induce cellular alignment and affect nuclear force transduction.
J Mech Behav Biomed Mater. 2023 Oct;146:106069. doi: 10.1016/j.jmbbm.2023.106069.
PMID: 37586175

Sartoneva R, Paakinaho K, Hannula M, Kuismanen K, Huhtala H, Hyttinen J, Miettinen S.
Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering.
Tissue Eng Regen Med. 2023 Oct 31. doi: 10.1007/s13770-023-00603-3.
PMID: 37907765

Kauppila M, Mörö A, Valle-Delgado JJ, Ihalainen T, Sukki L, Puistola P, Kallio P, Ilmarinen T, Österberg M, Skottman H.
Toward Corneal Limbus In Vitro Model: Regulation of hPSC-LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process.
Adv Healthc Mater. 2023 Nov;12(29):e2301396. doi: 10.1002/adhm.202301396.
PMID: 37449943

Rahikainen R, Vester SK, Turkki P, Janosko CP, Deiters A, Hytönen VP, Howarth M.
Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion.
J Am Chem Soc. 2023 Nov 15;145(45):24459-24465. doi: 10.1021/jacs.3c07827.
PMID: 38104267

Peussa H, Fedele C, Tran H, Marttinen M, Fadjukov J, Mäntylä E, Priimägi A, Nymark S, Ihalainen TO.
Light-Induced Nanoscale Deformation in Azobenzene Thin Film Triggers Rapid Intracellular Ca2+ Increase via Mechanosensitive Cation Channels.
Adv Sci (Weinh). 2023 Dec;10(35):e2206190. doi: 10.1002/advs.202206190.
PMID: 37946608

Terzioglu M, Veeroja K, Montonen T, Ihalainen TO, Salminen TS, Bénit P, Rustin P, Chang YT, Nagai T, Jacobs HT.
Mitochondrial temperature homeostasis resists external metabolic stresses.
Elife. 2023 Dec 11;12:RP89232. doi: 10.7554/eLife.89232. PMID: 38079477

Zapilko V, Moisio S, Parikka M, Heinäniemi M, Lohi O.
Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia.
Cancers (Basel). 2023 Dec 13;15(24):5821. doi: 10.3390/cancers15245821.
PMID: 38136366

Puistola P, Miettinen S, Skottman H, Mörö A.
Novel strategy for multi-material 3D bioprinting of human stem cell based corneal stroma with heterogenous design.
Mater Today Bio. 2023 Dec 22;24:100924. doi: 10.1016/j.mtbio.2023.100924.
PMID: 38226015
 
 

2022

Saari J, Siddique F, Korpela S, Mäntylä E, Ihalainen TO, Kaukinen K, Aalto-Setälä K, Lindfors K, Juuti-Uusitalo K.
Toward Xeno-Free Differentiation of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells.
Int J Mol Sci. 2022 Jan 24;23(3):1312. doi: 10.3390/ijms23031312.
PMID: 35163236

Viheriälä T, Hongisto H, Sorvari J, Skottman H, Nymark S, Ilmarinen T.
Cell maturation influences the ability of hESC-RPE to tolerate cellular stress.
Stem Cell Res Ther. 2022 Jan 24;13(1):30. doi: 10.1186/s13287-022-02712-7.
PMID: 35073969

Mykuliak A, Yrjänäinen A, Mäki AJ, Gebraad A, Lampela E, Kääriäinen M, Pakarinen TK, Kallio P, Miettinen S, Vuorenpää H.
Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip.
Front Bioeng Biotechnol. 2022 Feb 8;10:764237. doi: 10.3389/fbioe.2022.764237.
PMID: 35211462

Häkli M, Jäntti S, Joki T, Sukki L, Tornberg K, Aalto-Setälä K, Kallio P, Pekkanen-Mattila M, Narkilahti S.
Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip.
Int J Mol Sci. 2022 Mar 15;23(6):3148. doi: 10.3390/ijms23063148.
PMID: 35328569

Gaballah M, Penttinen K, Kreutzer J, Mäki AJ, Kallio P, Aalto-Setälä K.
Cardiac Ischemia On-a-Chip: Antiarrhythmic Effect of Levosimendan on Ischemic Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Cells. 2022 Mar 19;11(6):1045. doi: 10.3390/cells11061045.
PMID: 35326497

Fadjukov J, Wienbar S, Hakanen S, Aho V, Vihinen-Ranta M, Ihalainen TO, Schwartz GW, Nymark S.
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium.
J Gen Physiol. 2022 Apr 4;154(4):e202112916. doi: 10.1085/jgp.202112916.
PMID: 35275193

Mzezewa R, Lotila J, Kiiski H, Vinogradov A, Kapucu FE, Peltola J, Hagman S, Narkilahti S.
A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity.
Stem Cell Res. 2022 Apr;60:102665. doi: 10.1016/j.scr.2022.102665.
PMID: 35091307

Gebraad A, Ohlsbom R, Miettinen JJ, Emeh P, Pakarinen TK, Manninen M, Eskelinen A, Kuismanen K, Slipicevic A, Lehmann F, Nupponen NN, Heckman CA, Miettinen S.
Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen.
Cells. 2022 May 7;11(9):1574. doi: 10.3390/cells11091574.
PMID: 35563880

Peussa H, Kreutzer J, Mäntylä E, Mäki AJ, Nymark S, Kallio P, Ihalainen TO.
Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology.
PLoS One. 2022 Jun 3;17(6):e0268570. doi: 10.1371/journal.pone.0268570.
PMID: 35657824

Samanta S, Ylä-Outinen L, Rangasami VK, Narkilahti S, Oommen OP.
Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold.
Acta Biomater. 2022 Jul 15;147:439. doi: 10.1016/j.actbio.2022.05.025.
PMID: 35597769

Korkka I, Skottman H, Nymark S.
Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cells Transl Med. 2022 Jul 20;11(7):753-766. doi: 10.1093/stcltm/szac029.
PMID: 35639962

Azizi L, Varela L, Turkki P, Mykuliak VV, Korpela S, Ihalainen TO, Church J, Hytönen VP, Goult BT.
Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms.
Hum Mol Genet. 2022 Jul 21:ddac163. doi: 10.1093/hmg/ddac163.
PMID: 35861643

Maria Cherian R, Prajapati C, Penttinen K, Häkli M, Koivisto JT, Pekkanen-Mattila M, Aalto-Setälä K.
Fluorescent hiPSC-derived MYH6-mScarlet cardiomyocytes for real-time tracking, imaging, and cardiotoxicity assays.
Cell Biol Toxicol. 2022 Jul 23. doi: 10.1007/s10565-022-09742-0.
PMID: 35870039

Lotila J, Hyvärinen T, Skottman H, Airas L, Narkilahti S, Hagman S.
Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient.
Stem Cell Res. 2022 Aug;63:102865. doi: 10.1016/j.scr.2022.102865.
PMID: 35843021

Koivisto M, Tolvanen TA, Toimela T, Miinalainen I, Kiviaho A, Kesseli J, Nykter M, Eklund L, Heinonen T.
Functional human cell-based vascularised cardiac tissue model for biomedical research and testing.
Sci Rep. 2022 Aug 5;12(1):13459. doi: 10.1038/s41598-022-17498-0.
PMID: 35931748

Karttunen J, Heiskanen M, Joki T, Hyysalo A, Navarro-Ferrandis V, Miettinen S, Narkilahti S, Pitkänen A.
Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons.
Eur J Cell Biol. 2022 Sep-Nov;101(4):151270. doi: 10.1016/j.ejcb.2022.151270.
PMID: 35987046

Räsänen N, Harju V, Joki T, Narkilahti S.
Practical guide for preparation, computational reconstruction and analysis of 3D human neuronal networks in control and ischaemic conditions.
Development. 2022 Oct 15;149(20):dev200012. doi: 10.1242/dev.200012.
PMID: 35929583

Tornberg K, Välimäki H, Valaskivi S, Mäki AJ, Jokinen M, Kreutzer J, Kallio P.
Compartmentalized organ-on-a-chip structure for spatiotemporal control of oxygen microenvironments.
Biomed Microdevices. 2022 Oct 21;24(4):34. doi: 10.1007/s10544-022-00634-y.
PMID: 36269438

Gaertner K, Michell C, Tapanainen R, Goffart S, Saari S, Soininmäki M, Dufour E, Pohjoismäki JLO.
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae).
Mol Ecol. 2022 Nov 1. doi: 10.1111/mec.16755.
PMID: 36320183

Kukkonen K, Autio-Kimura B, Rauhala H, Kesseli J, Nykter M, Latonen L, Visakorpi T.
Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen.
Endocr Relat Cancer. 2022 Nov 7;29(12):717-733. doi: 10.1530/ERC-22-0108.
PMID: 36219867

Gering C, Párraga J, Vuorenpää H, Botero L, Miettinen S, Kellomäki M.
Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models.
Biomater Adv. 2022 Dec;143:213185. doi: 10.1016/j.bioadv.2022.213185.
PMID: 36371972

Häkli M, Kreutzer J, Mäki AJ, Välimäki H, Cherian RM, Kallio P, Aalto-Setälä K, Pekkanen-Mattila M.
Electrophysiological Changes of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes during Acute Hypoxia and Reoxygenation.
Stem Cells Int. 2022 Dec 19;2022:9438281. doi: 10.1155/2022/9438281.
PMID: 36579142

Mörö A, Samanta S, Honkamäki L, Rangasami VK, Puistola P, Kauppila M, Narkilahti S, Miettinen S, Oommen O, Skottman H.
Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation.
Biofabrication. 2022 Dec 29;15(1). doi: 10.1088/1758-5090/acab34.
PMID: 36579828
 
 

2021

Tan GSW, Liu Z, Ilmarinen T, Barathi VA, Chee CK, Lingam G, Su X, Stanzel BV.
Hints for Gentle Submacular Injection in Non-Human Primates Based on Intraoperative OCT Guidance.
Transl Vis Sci Technol. 2021 Jan 7;10(1):10. doi: 10.1167/tvst.10.1.10.
PMID: 33510949

Azizi L, Cowell AR, Mykuliak VV, Goult BT, Turkki P, Hytönen VP.
Cancer associated talin point mutations disorganise cell adhesion and migration.
Sci Rep. 2021 Jan 11;11(1):347. doi: 10.1038/s41598-020-77911-4.
PMID: 33431906

Viheriälä T, Sorvari J, Ihalainen TO, Mörö A, Grönroos P, Schlie-Wolter S, Chichkov B, Skottman H, Nymark S, Ilmarinen T.
Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE.
Sci Rep. 2021 Jan 13;11(1):933. doi: 10.1038/s41598-020-79638-8.
PMID: 33441679

Grönroos P, Ilmarinen T, Skottman H.
Directed Differentiation of Human Pluripotent Stem Cells towards Corneal Endothelial-Like Cells under Defined Conditions.
Cells. 2021 Feb 5;10(2):331. doi: 10.3390/cells10020331.
PMID: 33562615

Honkamäki L, Joki T, Grigoryev NA, Levon K, Ylä-Outinen L, Narkilahti S.
Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells.
J Neurosci Methods. 2021 Feb 15;350:109043. doi: 10.1016/j.jneumeth.2020.109043.
PMID: 33345946

Häkli M, Kreutzer J, Mäki AJ, Välimäki H, Lappi H, Huhtala H, Kallio P, Aalto-Setälä K, Pekkanen-Mattila M.
Human induced pluripotent stem cell-based platform for modeling cardiac ischemia.
Sci Rep. 2021 Feb 18;11(1):4153. doi: 10.1038/s41598-021-83740-w.
PMID: 33603154

Anton-Sales I, Koivusalo L, Skottman H, Laromaine A, Roig A.
Limbal Stem Cells on Bacterial Nanocellulose Carriers for Ocular Surface Regeneration.
Small. 2021 Mar;17(10):e2003937. doi: 10.1002/smll.202003937.
PMID: 33586332

Prajapati C, Ojala M, Lappi H, Aalto-Setälä K, Pekkanen-Mattila M.
Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods.
Stem Cell Res. 2021 Mar;51:102176. doi: 10.1016/j.scr.2021.102176.
PMID: 33485184

Eerola SK, Kohvakka A, Tammela TLJ, Koskinen PJ, Latonen L, Visakorpi T.
Expression and ERG regulation of PIM kinases in prostate cancer.
Cancer Med. 2021 May;10(10):3427-3436. doi: 10.1002/cam4.3893.
PMID: 33932111

George JJ, Oittinen M, Martin-Diaz L, Zapilko V, Iqbal S, Rintakangas T, Arrojo Martins FT, Niskanen H, Katajisto P, Kaikkonen MU, Viiri K.
Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development.
Cell Mol Gastroenterol Hepatol. 2021;12(3):873-889. doi: 10.1016/j.jcmgh.2021.05.014.
PMID: 34058415

Hytti M, Korhonen E, Hongisto H, Kaarniranta K, Skottman H, Kauppinen A.
Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration.
Int J Mol Sci. 2021 Jun 24;22(13):6800. doi: 10.3390/ijms22136800.
PMID: 34202702

Savijoki K, Myllymäki H, Luukinen H, Paulamäki L, Vanha-Aho LM, Svorjova A, Miettinen I, Fallarero A, Ihalainen TO, Yli-Kauhaluoma J, Nyman TA, Parikka M.
Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence.
mSystems. 2021 Jun 29;6(3):e0050021. doi: 10.1128/mSystems.00500-21.
PMID: 34156290

Liu Z, Ilmarinen T, Tan GSW, Hongisto H, Wong EYM, Tsai ASH, Al-Nawaiseh S, Holder GE, Su X, Barathi VA, Skottman H, Stanzel BV.
Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model.
Stem Cell Res Ther. 2021 Jul 27;12(1):423. doi: 10.1186/s13287-021-02395-6.
PMID: 34315534

Azizi L, Turkki P, Huynh N, Massera JM, Hytönen VP.
Surface Modification of Bioactive Glass Promotes Cell Attachment and Spreading.
ACS Omega. 2021 Aug 25;6(35):22635-22642. doi: 10.1021/acsomega.1c02669.
PMID: 34514235

George JJ, Martin-Diaz L, Ojanen MJT, Gasa R, Pesu M, Viiri K.
PRC2 Regulated Atoh8 Is a Regulator of Intestinal Microfold Cell (M Cell) Differentiation.
Int J Mol Sci. 2021 Aug 28;22(17):9355. doi: 10.3390/ijms22179355.
PMID: 34502262

Hyunh NB, Palma CSD, Rahikainen R, Mishra A, Azizi L, Verne E, Ferraris S, Hytönen VP, Sanches Ribeiro A, Massera J.
Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption.
ACS Biomater Sci Eng. 2021 Sep 13;7(9):4483-4493. doi: 10.1021/acsbiomaterials.1c00735.
PMID: 34382772

Mäntylä E, Ihalainen TO.
Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells.
Sci Rep. 2021 Sep 16;11(1):18520. doi: 10.1038/s41598-021-97900-5.
PMID: 34531455

Juntunen M, Heinonen S, Huhtala H, Rissanen A, Kaprio J, Kuismanen K, Pietiläinen KH, Miettinen S, Patrikoski M.
Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs.
Stem Cell Res Ther. 2021 Sep 26;12(1):516. doi: 10.1186/s13287-021-02587-0.
PMID: 34565451

Leppiniemi J, Mutahir Z, Dulebo A, Mikkonen P, Nuopponen M, Turkki P, Hytönen VP.
Avidin-Conjugated Nanofibrillar Cellulose Hydrogel Functionalized with Biotinylated Fibronectin and Vitronectin Promotes 3D Culture of Fibroblasts.
Biomacromolecules. 2021 Oct 11;22(10):4122-4137. doi: 10.1021/acs.biomac.1c00579.
PMID: 34542997

Coentro JQ, May U, Prince S, Zwaagstra J, Ritvos O, Järvinen TAH, Zeugolis DI.
Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies.
Front Bioeng Biotechnol. 2021 Oct 26;9:756399. doi: 10.3389/fbioe.2021.756399.
PMID: 34765594

Ahtiainen A, Genocchi B, Tanskanen JMA, Barros MT, Hyttinen JAK, Lenk K.
Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron-Astrocyte Co-Cultures.
Int J Mol Sci. 2021 Nov 25;22(23):12770. doi: 10.3390/ijms222312770.
PMID: 34884577

Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells.
iScience. 2021 Dec 18;25(1):103653. doi: 10.1016/j.isci.2021.103653.
PMID: 35024587

Vattulainen M, Ilmarinen T, Viheriälä T, Jokinen V, Skottman H.
Corneal epithelial differentiation of human pluripotent stem cells generates ABCB5+ and ∆Np63α+ cells with limbal cell characteristics and high wound healing capacity.
Stem Cell Res Ther. 2021 Dec 20;12(1):609. doi: 10.1186/s13287-021-02673-3.
PMID: 34930437

Järvelä-Stölting M, Vesala L, Maasdorp MK, Ciantar J, Rämet M, Valanne S.
Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.
Front Immunol. 2021 Dec 22;12:729631. doi: 10.3389/fimmu.2021.729631.
PMID: 35003057

Hernández-Pérez S, Runsala M, Šuštar V, Mattila PK.
Analysis of Intracellular Vesicles in B Lymphocytes: Antigen Traffic in the Spotlight.
Methods Mol Biol. 2021;2304:173-191. doi: 10.1007/978-1-0716-1402-0_9.
PMID: 34028717
 
 

2020

Calejo MT, Saari J, Vuorenpää H, Vuorimaa-Laukkanen E, Kallio P, Aalto-Setälä K, Miettinen S, Skottman H, Kellomäki M, Juuti-Uusitalo K.
Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films.
Acta Biomater. 2020 Jan 1;101:327-343. doi: 10.1016/j.actbio.2019.11.002.
PMID: 31711900

Halonen HT, Ihalainen TO, Hyväri L, Miettinen S, Hyttinen JAK.
Cell adhesion and culture medium dependent changes in the high frequency mechanical vibration induced proliferation, osteogenesis, and intracellular organization of human adipose stem cells.
J Mech Behav Biomed Mater. 2020 Jan;101:103419. doi: 10.1016/j.jmbbm.2019.103419.
PMID: 31518945

Harjula SE, Saralahti AK, Ojanen MJT, Rantapero T, Uusi-Mäkelä MIE, Nykter M, Lohi O, Parikka M, Rämet M.
Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio).
Dev Comp Immunol. 2020 Feb;103:103523. doi: 10.1016/j.dci.2019.103523.
PMID: 31626817

Kreutzer J, Viehrig M, Pölönen RP, Zhao F, Ojala M, Aalto-Setälä K, Kallio P.
Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.
Biomech Model Mechanobiol. 2020 Feb;19(1):291-303. doi: 10.1007/s10237-019-01211-8.
PMID: 31444593

Shah D, Prajapati C, Penttinen K, Cherian RM, Koivumäki JT, Alexanova A, Hyttinen J, Aalto-Setälä K.
hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells.
Cells. 2020 May 7;9(5):1153. doi: 10.3390/cells9051153.
PMID: 32392813

Välimäki H, Hyvärinen T, Leivo J, Iftikhar H, Pekkanen-Mattila M, Rajan DK, Verho J, Kreutzer J, Ryynänen T, Pirhonen J, Aalto-Setälä K, Kallio P, Narkilahti S, Lekkala J.
Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity.
Biomed Microdevices. 2020 Jun 3;22(2):41. doi: 10.1007/s10544-020-00495-3.
PMID: 32494857

Kohvakka A, Sattari M, Shcherban A, Annala M, Urbanucci A, Kesseli J, Tammela TLJ, Kivinummi K, Latonen L, Nykter M, Visakorpi T.
AR and ERG drive the expression of prostate cancer specific long noncoding RNAs.
Oncogene. 2020 Jul;39(30):5241-5251. doi: 10.1038/s41388-020-1365-6.
PMID: 32555329

Pemmari T, Ivanova L, May U, Lingasamy P, Tobi A, Pasternack A, Prince S, Ritvos O, Makkapati S, Teesalu T, Cairo MS, Järvinen TAH, Liao Y.
Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa.
Mol Ther. 2020 Aug 5;28(8):1833-1845. doi: 10.1016/j.ymthe.2020.05.017.
PMID: 32497513

Fedele C, Mäntylä E, Belardi B, Hamkins-Indik T, Cavalli S, Netti PA, Fletcher DA, Nymark S, Priimagi A, Ihalainen TO.
Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells.
Sci Rep. 2020 Sep 18;10(1):15329. doi: 10.1038/s41598-020-71567-w.
PMID: 32948792

Hyväri L, Vanhatupa S, Halonen HT, Kääriäinen M, Miettinen S.
Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells.
Stem Cells Int. 2020 Sep 22;2020:8853541. doi: 10.1155/2020/8853541.
PMID: 33029150

Hongisto H, Dewing JM, Christensen DR, Scott J, Cree AJ, Nättinen J, Määttä J, Jylhä A, Aapola U, Uusitalo H, Kaarniranta K, Ratnayaka JA, Skottman H, Lotery AJ.
In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby fundus dystrophy.
J Pathol. 2020 Oct;252(2):138-150. doi: 10.1002/path.5506.
PMID: 32666594

Tamminen I, Lehto K, Hannula M, Ojansivu M, Johansson L, Kellomäki M, Miettinen S, Aula A, Ihalainen T, Hyttinen J.
A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples.
Commun Biol. 2020 Oct 2;3(1):548. doi: 10.1038/s42003-020-01273-w.
PMID: 33009501

Juntunen M, Hagman S, Moisan A, Narkilahti S, Miettinen S.
In Vitro Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons.
Stem Cells Int. 2020 Oct 29;2020:8841026. doi: 10.1155/2020/8841026.
PMID: 33178286

Honkimaa A, Kimura B, Sioofy-Khojine AB, Lin J, Laiho J, Oikarinen S, Hyöty H.
Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells.
Microorganisms. 2020 Nov 15;8(11):1790. doi: 10.3390/microorganisms8111790.
PMID: 33203081

Pelkonen A, Mzezewa R, Sukki L, Ryynänen T, Kreutzer J, Hyvärinen T, Vinogradov A, Aarnos L, Lekkala J, Kallio P, Narkilahti S.
A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks.
Biosens Bioelectron. 2020 Nov 15;168:112553. doi: 10.1016/j.bios.2020.112553.
PMID: 32877779

Jäntti T, Luhtala S, Mäenpää J, Staff S.
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Tumour Biol. 2020 Nov;42(11):1010428320971404. doi: 10.1177/1010428320971404.
PMID: 33169632

Rasheed A, Azizi L, Turkki P, Janka M, Hytönen VP, Tuukkanen S.
Extrusion-Based Bioprinting of Multilayered Nanocellulose Constructs for Cell Cultivation Using In Situ Freezing and Preprint CaCl2 Cross-Linking.
ACS Omega. 2020 Dec 30;6(1):569-578. doi: 10.1021/acsomega.0c05036.
PMID: 33458509
 
 

2019

Karvinen J, Ihalainen TO, Calejo MT, Jönkkäri I, Kellomäki M.
Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studies.
Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:1056-1066. doi: 10.1016/j.msec.2018.10.048.
PMID: 30423686

Valanne S, Salminen TS, Järvelä-Stölting M, Vesala L, Rämet M.
Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster.
PLoS Pathog. 2019 Jan 11;15(1):e1007504. doi: 10.1371/journal.ppat.1007504.
PMID: 30633769

Korkka I, Viheriälä T, Juuti-Uusitalo K, Uusitalo-Järvinen H, Skottman H, Hyttinen J, Nymark S.
Functional Voltage-Gated Calcium Channels Are Present in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.
Stem Cells Transl Med. 2019 Feb;8(2):179-193. doi: 10.1002/sctm.18-0026.
PMID: 30394009

Viiri LE, Rantapero T, Kiamehr M, Alexanova A, Oittinen M, Viiri K, Niskanen H, Nykter M, Kaikkonen MU, Aalto-Setälä K.
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation.
Sci Rep. 2019 Mar 5;9(1):3562. doi: 10.1038/s41598-019-39215-0.
PMID: 30837492

González de Cózar JM, Gerards M, Teeri E, George J, Dufour E, Jacobs HT, Jõers P.
RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.
J Biol Chem. 2019 Mar 22;294(12):4331-4344. doi: 10.1074/jbc.RA118.007015.
PMID: 30635398

Aspatwar A, Tolvanen MEE, Schneider HP, Becker HM, Narkilahti S, Parkkila S, Deitmer JW.
Catalytically-inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.
FEBS Open Bio. 2019 Apr 29. doi: 10.1002/2211-5463.12647.
PMID: 31033227

Rahikainen R, Öhman T, Turkki P, Varjosalo M, Hytönen VP.
Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling.
J Cell Sci. 2019 Apr 3;132(7). pii: jcs226514. doi: 10.1242/jcs.226514.
PMID: 30837291

Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O.
Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.
J Allergy Clin Immunol. 2019 Apr;143(4):1549-1559.e6. doi: 10.1016/j.jaci.2018.07.022.
PMID: 30092288

Alarautalahti V, Ragauskas S, Hakkarainen JJ, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S.
Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology.
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1914-1927. doi: 10.1167/iovs.18-25156.
PMID: 31042799

Pekkanen-Mattila M, Häkli M, Pölönen RP, Mansikkala T, Junnila A, Talvitie E, Koivisto JT, Kellomäki M, Aalto-Setälä K.
Polyethylene Terephthalate Textiles Enhance the Structural Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Materials (Basel). 2019 Jun 3;12(11). pii: E1805. doi: 10.3390/ma12111805.
PMID: 31163704

Koivisto JT, Gering C, Karvinen J, Maria Cherian R, Belay B, Hyttinen J, Aalto-Setälä K, Kellomäki M, Parraga J.
Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes.
ACS Appl Mater Interfaces. 2019 Jun 12;11(23):20589-20602. doi: 10.1021/acsami.8b22343.
PMID: 31120238

Vuornos K, Ojansivu M, Koivisto JT, Häkkänen H, Belay B, Montonen T, Huhtala H, Kääriäinen M, Hupa L, Kellomäki M, Hyttinen J, Ihalainen JA, Miettinen S.
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:905-918. doi: 10.1016/j.msec.2019.02.035.
PMID: 30889765

Aspatwar A, Tolvanen MEE, Schneider HP, Becker HM, Narkilahti S, Parkkila S, Deitmer JW.
Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.
FEBS Open Bio. 2019 Jul;9(7):1204-1211. doi: 10.1002/2211-5463.12647.
PMID: 31033227

Ylä-Outinen L, Harju V, Joki T, Koivisto JT, Karvinen J, Kellomäki M, Narkilahti S.
Screening of Hydrogels for Human Pluripotent Stem Cell-Derived Neural Cells: Hyaluronan-Polyvinyl Alcohol-Collagen-Based Interpenetrating Polymer Network Provides an Improved Hydrogel Scaffold.
Macromol Biosci. 2019 Jul;19(7):e1900096. doi: 10.1002/mabi.201900096.
PMID: 31173471

Kiamehr M, Klettner A, Richert E, Koskela A, Koistinen A, Skottman H, Kaarniranta K, Aalto-Setälä K, Juuti-Uusitalo K.
Compromised Barrier Function in Human Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells from Type 2 Diabetic Patients.
Int J Mol Sci. 2019 Aug 1;20(15). pii: E3773. doi: 10.3390/ijms20153773.
PMID: 31375001

Vattulainen M, Ilmarinen T, Koivusalo L, Viiri K, Hongisto H, Skottman H.
Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential.
Stem Cell Res Ther. 2019 Aug 5;10(1):236. doi: 10.1186/s13287-019-1354-2.
PMID:31383008

Johansson JK, Karema-Jokinen VI, Hakanen S, Jylhä A, Uusitalo H, Vihinen-Ranta M, Skottman H, Ihalainen TO, Nymark S.
Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium.
BMC Biol. 2019 Aug 15;17(1):63. doi: 10.1186/s12915-019-0681-1.
PMID: 31412898

Gering C, Koivisto JT, Parraga J, Leppiniemi J, Vuornos K, Hytönen VP, Miettinen S, Kellomäki M.
Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications.
PLoS One. 2019 Aug 30;14(8):e0221931. doi: 10.1371/journal.pone.0221931.
PMID: 31469884

Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R.
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.
iScience. 2019 Sep 27;19:340-357. doi: 10.1016/j.isci.2019.07.040.
PMID: 31404834

Bahhir D, Yalgin C, Ots L, Järvinen S, George J, Naudí A, Krama T, Krams I, Tamm M, Andjelković A, Dufour E, González de Cózar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Jõers P.
Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms.
PLoS Genet. 2019 Oct 4;15(10):e1008410. doi: 10.1371/journal.pgen.1008410.
PMID: 31584940

Harjula SE, Saralahti AK, Ojanen MJT, Rantapero T, Uusi-Mäkelä MIE, Nykter M, Lohi O, Parikka M, Rämet M.
Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio).
Dev Comp Immunol. 2019 Oct 15;103:103523. doi: 10.1016/j.dci.2019.103523.
PMID: 31626817

Calejo MT, Saari J, Vuorenpää H, Vuorimaa-Laukkanen E, Kallio P, Aalto-Setälä K, Miettinen S, Skottman H, Kellomäki M, Juuti-Uusitalo K.
Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films.
Acta Biomater. 2019 Nov 8. pii: S1742-7061(19)30742-1. doi: 10.1016/j.actbio.2019.11.002.
PMID: 31711900

Hyvärinen T, Hyysalo A, Kapucu F.E, Aarnos L, Vinogradov A, Eglen S.J, Ylä-Outinen L, Narkilahti S.
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.
Sci Rep. 2019 Nov 15;9(1):16944. doi: 10.1038/s41598-019-53414-9.
PMID: 31729450

Hyvärinen T, Hyysalo A, Kapucu FE, Aarnos L, Vinogradov A, Eglen SJ, Ylä-Outinen L, Narkilahti S.
Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures.
Sci Rep. 2019 Nov 20;9(1):17125. doi: 10.1038/s41598-019-53647-8.
PMID: 31748598

Keeble AH, Turkki P, Stokes S, Khairil Anuar INA, Rahikainen R, Hytönen VP, Howarth M.
Approaching infinite affinity through engineering of peptide-protein interaction.
Proc Natl Acad Sci U S A. 2019 Dec 10;116(52):26523-33. doi: 10.1073/pnas.1909653116.
PMID: 31822621

Koivusalo L, Kauppila M, Samanta S, Parihar VS, Ilmarinen T, Miettinen S, Oommen OP, Skottman H.
Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma.
Biomaterials. 2019 Dec;225:119516. doi: 10.1016/j.biomaterials.2019.119516.
PMID: 31574405
 
 

2018

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH.
A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.
Sci Rep. 2018 Jan 8;8(1):33. doi: 10.1038/s41598-017-18495-4.
PMID: 29311608

Gerards M, Cannino G, de Cózar JMG, Jacobs HT.
Intracellular vesicle trafficking plays an essential role in mitochondrial quality control.
Mol Biol Cell. 2018 Jan 17. pii: mbc.E17-10-0619. doi: 10.1091/mbc.E17-10-0619.
PMID: 29343549

Ojansivu M, Wang X, Hyväri L, Kellomäki M, Hupa L, Vanhatupa S, Miettinen S.
Bioactive glass induced osteogenic differentiation of human adipose stem cells is dependent on cell attachment mechanism and mitogen-activated protein kinases.
Eur Cell Mater. 2018 Jan; 35:54-72. doi: 10.22203/eCM.v035a05.
PMID: 29383695

Vähätupa M, Cordova ZM, Barker H, Aittomäki S, Uusitalo H, Järvinen TAH, Pesu M, Uusitalo-Järvinen H.
Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy.
Exp Eye Res. 2018 Jan;166:160-167. doi: 10.1016/j.exer.2017.10.013.
PMID: 29031855

Aspatwar A, Haapanen S, Parkkila S.
An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.
Metabolites. 2018 Mar 13;8(1). pii: E22. doi: 10.3390/metabo8010022.
PMID: 29534024

Vuorinen EM, Rajala NK, Ihalainen TO, Kallioniemi A.
Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells.
BMC Cancer. 2018 Mar 27;18(1):325. doi: 10.1186/s12885-018-4261-5.
PMID: 29580221

Paavilainen T, Pelkonen A, Mäkinen ME, Peltola M, Huhtala H, Fayuk D, Narkilahti S.
Effect of prolonged differentiation on functional maturation of human pluripotent stem cell-derived neuronal cultures.
Stem Cell Res. 2018 Mar;27:151-161. doi: 10.1016/j.scr.2018.01.018.
PMID: 29414606

Koivusalo L, Karvinen J, Sorsa E, Jönkkäri I, Väliaho J, Kallio P, Ilmarinen T, Miettinen S, Skottman H, Kellomäki M.
Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects.
Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:68-78. doi: 10.1016/j.msec.2017.12.013.
PMID: 29407158

Ojansivu M, Johansson L, Vanhatupa S, Tamminen I, Hannula M, Hyttinen J, Kellomäki M, Miettinen S.
Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis.
Stem Cells Int. 2018 May 7;2018:5928935. doi: 10.1155/2018/5928935.
PMID: 29853915

Vähätupa M, Nättinen J, Jylhä A, Aapola U, Kataja M, Kööbi P, Järvinen TAH, Uusitalo H, Uusitalo-Järvinen H.
SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets.
Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3294-3306. doi: 10.1167/iovs.18-23831.
PMID: 30025079

Prajapati C, Pölönen RP, Aalto-Setälä K.
Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes.
Biol Open. 2018 Jul 16;7(7). pii: bio035030. doi: 10.1242/bio.035030.
PMID: 29970475

Abu Khamidakh AE, Rodriguez-Martinez A, Kaarniranta K, Kallioniemi A, Skottman H, Hyttinen J, Juuti-Uusitalo K.
Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage.
Biomed Eng Online. 2018 Jul 31;17(1):102. doi: 10.1186/s12938-018-0535-z.
PMID: 30064430

Sorkio A, Koch L, Koivusalo L, Deiwick A, Miettinen S, Chichkov B, Skottman H.
Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks.
Biomaterials. 2018 Jul;171:57-71. doi: 10.1016/j.biomaterials.2018.04.034.
PMID: 29684677

Hammarén HM, Virtanen AT, Abraham BG, Peussa H, Hubbard SR, Silvennoinen O.
Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations.
J Allergy Clin Immunol. 2018 Aug 6. pii: S0091-6749(18)31129-1. doi: 10.1016/j.jaci.2018.07.022.
PMID: 30092288

Sartoneva R, Kuismanen K, Juntunen M, Karjalainen S, Hannula M, Kyllönen L, Hyttinen J, Huhtala H, Paakinaho K, Miettinen S.
Porous poly-l-lactide-co-ɛ-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering.
R Soc Open Sci. 2018 Aug 15;5(8):180811. doi: 10.1098/rsos.180811.
PMID: 30225072

Ojansivu M, Mishra A, Vanhatupa S, Juntunen M, Larionova A, Massera J, Miettinen S.
The effect of S53P4-based borosilicate glasses and glass dissolution products on the osteogenic commitment of human adipose stem cells.
PLoS One. 2018 Aug 28;13(8):e0202740. doi: 10.1371/journal.pone.0202740.
PMID: 30153295

Hagman S, Mäkinen A, Ylä-Outinen L, Huhtala H, Elovaara I, Narkilahti S.
Effects of inflammatory cytokines IFN-γ, TNF-α and IL-6 on the viability and functionality of human pluripotent stem cell-derived neural cells.
J Neuroimmunol. 2018 Aug 29. pii: S0165-5728(17)30480-0. doi: 10.1016/j.jneuroim.2018.07.010.
PMID: 30195439

Hyväri L, Ojansivu M, Juntunen M, Kartasalo K, Miettinen S, Vanhatupa S.
Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages.
Stem Cells Int. 2018 Sep 12;2018:2190657. doi: 10.1155/2018/2190657.
PMID: 30275837

Hongisto H, Vattulainen M, Ilmarinen T, Mikhailova A, Skottman H.
Efficient and Scalable Directed Differentiation of Clinically Compatible Corneal Limbal Epithelial Stem Cells from Human Pluripotent Stem Cells.
J Vis Exp. 2018 Oct 24;(140). doi: 10.3791/58279.
PMID: 30417867

Andjelković A, Mordas A, Bruinsma L, Ketola A, Cannino G, Giordano L, Dhandapani PK, Szibor M, Dufour E, Jacobs HT.
Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration.
Mol Cell Biol. 2018 Nov 28;38(24). pii: e00110-18. doi: 10.1128/MCB.00110-18.
PMID: 30224521

Ryynänen T, Toivanen M, Salminen T, Ylä-Outinen L, Narkilahti S, Lekkala J.
Ion Beam Assisted E-Beam Deposited TiN Microelectrodes-Applied to Neuronal Cell Culture Medium Evaluation.
Front Neurosci. 2018 Dec 4;12:882. doi: 10.3389/fnins.2018.00882.
PMID: 30568570

Ilmarinen T, Thieltges F, Hongisto H, Juuti-Uusitalo K, Koistinen A, Kaarniranta K, Brinken R, Braun N, Holz FG, Skottman H, Stanzel BV.
Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.
Acta Ophthalmol. 2018 Dec 28. doi: 10.1111/aos.14004.
PMID: 30593729
 
 

2017

Kumar M, Rahikainen R, Unruh D, Hytönen VP, Delbrück C, Sindelar R, Renz F.
Mixture of PLA-PEG and biotinylated albumin enables immobilization of avidins on electrospun fibers.
J Biomed Mater Res A. 2017 Feb;105(2):356-362. doi: 10.1002/jbm.a.35920.
PMID: 27684712

Kreutzer J, Ylä-Outinen L, Mäki AJ, Ristola M, Narkilahti S, Kallio P.
Cell culture chamber with gas supply for prolonged recording of human neuronal cells on microelectrode array.
J Neurosci Methods. 2017 Mar 15;280:27-35. doi: 10.1016/j.jneumeth.2017.01.019.
PMID: 28161299

Koivisto JT, Joki T, Parraga JE, Pääkkönen R, Ylä-Outinen L, Salonen L, Jönkkäri I, Peltola M, Ihalainen TO, Narkilahti S, Kellomäki M.
Bioamine-crosslinked gellan gum hydrogel for neural tissue engineering.
Biomed Mater. 2017 Mar 24;12(2):025014. doi: 10.1088/1748-605X/aa62b0.
PMID: 28233757

Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen JMT, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K.
Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Int J Mol Sci. 2017 May 19;18(5). pii: E1089. doi: 10.3390/ijms18051089.
PMID: 28534814

Oksala NKJ, Seppälä I, Rahikainen R, Mäkelä KM, Raitoharju E, Illig T, Klopp N, Kholova I, Laaksonen R, Karhunen PJ, Hytönen VP, Lehtimäki T.
Synergistic Expression of Histone Deacetylase 9 and Matrix Metalloproteinase 12 in M4 Macrophages in Advanced Carotid Plaques.
Eur J Vasc Endovasc Surg. 2017 May;53(5):632-640. doi: 10.1016/j.ejvs.2017.02.014.
PMID: 28343758

Calejo MT, Ilmarinen T, Vuorimaa-Laukkanen E, Talvitie E, Hakola HM, Skottman H, Kellomäki M.
Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering.
Acta Biomater. 2017 May;54:138-149. doi: 10.1016/j.actbio.2017.02.035.
PMID: 28223209

Rahikainen R, von Essen M, Schaefer M, Qi L, Azizi L, Kelly C, Ihalainen TO, Wehrle-Haller B, Bastmeyer M, Huang C, Hytönen VP.
Mechanical stability of talin rod controls cell migration and substrate sensing.
Sci Rep. 2017 Jun 15;7(1):3571. doi: 10.1038/s41598-017-03335-2.
PMID: 2862017

Saari S, Andjelković A, Garcia GS, Jacobs HT, Oliveira MT.
Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster.
BMC Dev Biol. 2017 Jul 3;17(1):9. doi: 10.1186/s12861-017-0151-3.
PMID: 28673232

Leppiniemi J, Lahtinen P, Paajanen A, Mahlberg R, Metsä-Kortelainen S, Pinomaa T, Pajari H, Vikholm-Lundin I, Pursula P, Hytönen VP.
3D-Printable Bioactivated Nanocellulose-Alginate Hydrogels.
ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21959-21970. doi: 10.1021/acsami.7b02756.
PMID: 28598154

Leivo J, Virjula S, Vanhatupa S, Kartasalo K, Kreutzer J, Miettinen S, Kallio P.
A durable and biocompatible ascorbic acid-based covalent coating method of polydimethylsiloxane for dynamic cell culture.
J R Soc Interface. 2017 Jul;14(132). pii: 20170318. doi: 10.1098/rsif.2017.0318.
PMID: 28747398

Hyysalo A, Ristola M, Joki T, Honkanen M, Vippola M, Narkilahti S.
Aligned Poly(ε-caprolactone) Nanofibers Guide the Orientation and Migration of Human Pluripotent Stem Cell-Derived Neurons, Astrocytes, and Oligodendrocyte Precursor Cells In Vitro.
Macromol Biosci. 2017 Jul;17(7). doi: 10.1002/mabi.201600517.
PMID: 28296144

Skottman H, Muranen J, Lähdekorpi H, Pajula E, Mäkelä K, Koivusalo L, Koistinen A, Uusitalo H, Kaarniranta K, Juuti-Uusitalo K.
Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells.
Exp Cell Res. 2017 Aug 8. pii: S0014-4827(17)30415-9. doi: 10.1016/j.yexcr.2017.08.004.
PMID: 28800962

Turunen S, Joki T, Hiltunen ML, Ihalainen TO, Narkilahti S, Kellomäki M.
Direct Laser Writing of Tubular Microtowers for 3D Culture of Human Pluripotent Stem Cell-Derived Neuronal Cells.
ACS Appl Mater Interfaces. 2017 Aug 9;9(31):25717-25730. doi: 10.1021/acsami.7b05536.
PMID: 28697300

Virjula S, Zhao F, Leivo J, Vanhatupa S, Kreutzer J, Vaughan TJ, Honkala AM, Viehrig M, Mullen CA, Kallio P, McNamara LM, Miettinen S.
The effect of equiaxial stretching on the osteogenic differentiation and mechanical properties of human adipose stem cells.
J Mech Behav Biomed Mater. 2017 Aug;72:38-48. doi: 10.1016/j.jmbbm.2017.04.016.
PMID: 28448920

Kiamehr M, Viiri LE, Vihervaara T, Koistinen KM, Hilvo M, Ekroos K, Käkelä R, Aalto-Setälä K.
Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.
Dis Model Mech. 2017 Sep 1;10(9):1141-1153. doi: 10.1242/dmm.030841.
PMID: 28733363

Hyysalo A, Ristola M, Mäkinen ME, Häyrynen S, Nykter M, Narkilahti S.
Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro.
Stem Cell Res. 2017 Sep 12;24:118-127. doi: 10.1016/j.scr.2017.09.002.
PMID: 28926760

Vuorenpää H, Penttinen K, Heinonen T, Pekkanen-Mattila M, Sarkanen JR, Ylikomi T, Aalto-Setälä K.
Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct.
Cytotechnology. 2017 Oct;69(5):785-800. doi: 10.1007/s10616-017-0088-1.
PMID: 28397099

Sorkio A, Haimi S, Verdoold V, Juuti-Uusitalo K, Grijpma D, Skottman H.
Poly(trimethylene carbonate) as an elastic biodegradable film for human embryonic stem cell-derived retinal pigment epithelial cells.
J Tissue Eng Regen Med. 2017 Nov;11(11):3134-3144. doi: 10.1002/term.2221.
PMID:28052579

Hongisto H, Ilmarinen T, Vattulainen M, Mikhailova A, Skottman H.
Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method.
Stem Cell Res Ther. 2017 Dec 29;8(1):291. doi: 10.1186/s13287-017-0738-4.
PMID:29284513
 
 

2016

Kemppainen E, George J, Garipler G, Tuomela T, Kiviranta E, Soga T, Dunn CD, Jacobs HT.
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.
PLoS One. 2016 Mar 8;11(3):e0151421. doi: 10.1371/journal.pone.0151421.
PMID: 26954062

Vuornos K, Björninen M, Talvitie E, Paakinaho K, Kellomäki M, Huhtala H, Miettinen S, Seppänen-Kaijansinkko R, Haimi S.
Human Adipose Stem Cells Differentiated on Braided Polylactide Scaffolds Is a Potential Approach for Tendon Tissue Engineering.
Tissue Eng Part A. 2016 Mar;22(5-6):513-23. doi: 10.1089/ten.tea.2015.0276.
PMID: 26919401

Calejo MT, Ilmarinen T, Jongprasitkul H, Skottman H, Kellomäki M.
Honeycomb porous films as permeable scaffold materials for human embryonic stem cell-derived retinal pigment epithelium.
J Biomed Mater Res A. 2016 Jul;104(7):1646-56. doi: 10.1002/jbm.a.35690.
PMID: 26914698

Anderl I, Vesala L, Ihalainen TO, Vanha-Aho LM, Andó I, Rämet M, Hultmark D.
Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection.
PLoS Pathog. 2016 Jul 14;12(7):e1005746. doi: 10.1371/journal.ppat.1005746.
PMID: 27414410

Hynninen V, Vuori L, Hannula M, Tapio K, Lahtonen K, Isoniemi T, Lehtonen E, Hirsimäki M, Toppari JJ, Valden M, Hytönen VP.
Improved antifouling properties and selective biofunctionalization of stainless steel by employing heterobifunctional silane-polyethylene glycol overlayers and avidin-biotin technology.
Sci Rep. 2016 Jul 6;6:29324. doi: 10.1038/srep29324.
PMID: 27381834

Lenk K, Priwitzer B, Ylä-Outinen L, Tietz LH, Narkilahti S, Hyttinen JA.
Simulation of developing human neuronal cell networks.
Biomed Eng Online. 2016 Aug 30;15(1):105. doi: 10.1186/s12938-016-0226-6.
PMID: 27576323

Andjelković A, Kemppainen KK, Jacobs HT.
Ligand-Bound GeneSwitch Causes Developmental Aberrations in Drosophila that Are Alleviated by the Alternative Oxidase.
G3 (Bethesda). 2016 Sep 8;6(9):2839-46. doi: 10.1534/g3.116.030882.
PMID: 27412986

von Essen M, Rahikainen R, Oksala N, Raitoharju E, Seppälä I, Mennander A, Sioris T, Kholová I, Klopp N, Illig T, Karhunen PJ, Kähönen M, Lehtimäki T, Hytönen VP.
Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
Atherosclerosis. 2016 Dec;255:43-53. doi: 10.1016/j.atherosclerosis.2016.10.031.
PMID: 27816808
 
 

2015

Faia-Torres AB, Goren T, Ihalainen TO, Guimond-Lischer S, Charnley M, Rottmar M, Maniura-Weber K, Spencer ND, Reis RL, Textor M, Neves NM.
Regulation of human mesenchymal stem cell osteogenesis by specific surface density of fibronectin: a gradient study.
ACS Appl Mater Interfaces. 2015 Feb 4;7(4):2367-75. doi: 10.1021/am506951c.
PMID: 25513839

Vanha-Aho LM, Anderl I, Vesala L, Hultmark D, Valanne S, Rämet M.
Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster.
PLoS Pathog. 2015 May 12;11(5):e1004895. doi: 10.1371/journal.ppat.1004895.
PMID: 25965263

Ribeiro C, Pärssinen J, Sencadas V, Correia V, Miettinen S, Hytönen VP, Lanceros-Méndez S.
Dynamic piezoelectric stimulation enhances osteogenic differentiation of human adipose stem cells.
J Biomed Mater Res A. 2015 Jun;103(6):2172-5. doi: 10.1002/jbm.a.35368.
PMID: 25370596

Syrjänen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Rämet M, Parkkila S.
β carbonic anhydrase is required for female fertility in Drosophila melanogaster.
Front Zool. 2015 Aug 22;12:19. doi: 10.1186/s12983-015-0111-3.
PMID: 26300950

Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP.
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Atherosclerosis. 2015 Sep;242(1):145-54. doi: 10.1016/j.atherosclerosis.2015.06.058.
PMID: 26188538

Koho T, Ihalainen TO, Stark M, Uusi-Kerttula H, Wieneke R, Rahikainen R, Blazevic V, Marjomäki V, Tampé R, Kulomaa MS, Hytönen VP.
His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display.
Eur J Pharm Biopharm. 2015 Oct;96:22-31. doi: 10.1016/j.ejpb.2015.07.002.
PMID: 26170162

Ihalainen TO, Aires L, Herzog FA, Schwartlander R, Moeller J, Vogel V.
Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension.
Nat Mater. 2015 Dec;14(12):1252-61. doi: 10.1038/nmat4389.
PMID: 26301768
 
 

2014

Rajala N, Gerhold JM, Martinsson P, Klymov A, Spelbrink JN.
Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication.
Nucleic Acids Res. 2014 Jan;42(2):952-67. doi: 10.1093/nar/gkt988.
PMID: 24163258

Kemppainen KK, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, Popplestone A, Singh S, Sanz A, Rustin P, Jacobs HT.
Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency.
Hum Mol Genet. 2014 Apr 15;23(8):2078-93. doi: 10.1093/hmg/ddt601.
PMID: 24293544

Vartiainen S, Chen S, George J, Tuomela T, Luoto KR, O'Dell KM, Jacobs HT.
Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease.
Dis Model Mech. 2014 Jun;7(6):635-48. doi: 10.1242/dmm.016527.
PMID: 24812436

Fukuoh A, Cannino G, Gerards M, Buckley S, Kazancioglu S, Scialo F, Lihavainen E, Ribeiro A, Dufour E, Jacobs HT.
Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase.
Mol Syst Biol. 2014 Jun 21;10:734. doi: 10.15252/msb.20145117.
PMID: 24952591