KEB-23406 Metabolic Engineering, 4 cr
Additional information
The course is lectured every other year (2017, 2019,...).
In the years of no implementation, the course can be accomplished by a book exam and defined assigments (please contact the course teacher).
Suitable for postgraduate studies
Will not be lectured year 2015-2016
Person responsible
Suvi Santala, Ville Santala
-->Requirements
Mandatory laboratory exercises, seminars, and an exam.
Completion parts must belong to the same implementation
Learning Outcomes
After passing the course the student can link changes in the genotype level to changes in the phenotype level. The student will have an understanding of in silico metabolic models in metabolic engineering and their interplay with in vivo methods. The student will be able to apply metabolic engineering to different problems in modern industrial microbe strain improvement. The course will include a practical case example during which the student will carry out a short laboratory project exemplifying the power of metabolic engineering. The student will obtain up to date information about the latest proceedings in metabolic engineering and synthetic biology.
Content
| Content | Core content | Complementary knowledge | Specialist knowledge |
| 1. | Methods in metabolic engineering: in silico | ||
| 2. | Methods in metabolic engineering: in vivo. Tools and methods for genetic engineering in bacteria. | Synthetic biology Protein engineering and evolution | |
| 3. | Microbial metabolism | Metabolic pathways | |
| 4. | Gene expression | Regulation of gene expression | |
| 5. | Case example: in silico and in vivo laboratory |
Instructions for students on how to achieve the learning outcomes
The grade will be determined on the basis of an exam, seminar work, and written laboratory report. To pass the course with a grade 1 the student will have to score at least 50 % of the maximum points in the exam. A good understanding of the core content will suffice to a grade 3. In order to earn a grade 4 or 5 the student will have to have a good or excellent understanding of complementary knowledge.
Assessment scale:
Numerical evaluation scale (1-5) will be used on the course
Partial passing:
Study material
| Type | Name | Author | ISBN | URL | Additional information | Examination material |
| Lecture slides | Metabolic engineering | Suvi Santala | Yes | |||
| Lecture slides | Metabolic engineering | Ville Santala | Yes |
Prerequisites
| Course | Mandatory/Advisable | Description |
| KEB-23736 Industrial and Molecular Biotechnology | Mandatory | 1 |
1 . or corresponding course(s)
Correspondence of content
| Course | Corresponds course | Description |
| KEB-23406 Metabolic Engineering, 4 cr | BIO-2626 Metabolic Engineering, 4 cr |